WITHAFERIN A
- Product Name
- WITHAFERIN A
- CAS No.
- 5119-48-2
- Chemical Name
- WITHAFERIN A
- Synonyms
- NSC 273757;nsc-101088;upeferinA.;Withaferine;WITHAFERIN A;withaferinea;Withaferin A Standard;Withaferin A 5119-48-2;delta-lactone,(20s,22r)-oxo;Withaferin A from leaves of Withania somnifera
- CBNumber
- CB9454365
- Molecular Formula
- C28H38O6
- Formula Weight
- 470.6
- MOL File
- 5119-48-2.mol
WITHAFERIN A Property
- Melting point:
- 252-253℃
- alpha
- D28 +125° (c = 1.30 in CHCl3)
- Boiling point:
- 680.7±55.0 °C(Predicted)
- Density
- 1.28
- Flash point:
- 226℃
- storage temp.
- Desiccate at -20°C
- solubility
- Soluble in DMSO (up to 20 mg/ml)
- pka
- 13.49±0.70(Predicted)
- form
- White solid
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
- InChIKey
- DBRXOUCRJQVYJQ-CKNDUULBSA-N
Safety
- Hazard Codes
- T
- WGK Germany
- 3
- RTECS
- KE7288500
- HS Code
- 29322090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- PHL89824
- Product name
- Withaferin A
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $553
- Updated
- 2024/03/01
- Product number
- 681535
- Product name
- Withaferin A
- Packaging
- 1mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 681535
- Product name
- Withaferin A
- Packaging
- 5mg
- Price
- $504
- Updated
- 2024/03/01
- Product number
- 11352
- Product name
- Withaferin A
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 11352
- Product name
- Withaferin A
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $238
- Updated
- 2024/03/01
WITHAFERIN A Chemical Properties,Usage,Production
Description
Withaferin A (5119-48-2) displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro?(IC50?= 12 nM) and?in vivo.1?Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2?Covalently binds to the intermediate filament protein, vimentin3?inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis in?in vivo?models.5
Chemical Properties
Solid
Uses
Withaferin A is a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera. Withaferin A showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986). Withaferin A has recently been found to be a leptin sensitizer that can reduce the weight in obese mice fed in a high-fat diet (see C249500).
Definition
ChEBI: A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Phys lis longifolia, it exhibits cytotoxic activity.
Biological Activity
Steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) spouting in vitro (IC 50 = 12 nM) and in vivo . Prevents NF- κ B activation by inhibiting activation of IKK β . Also inhibits chymotrypsin-like activity of the 20S proteasome.
target
ROS | NF-kB | p53 | STAT | PARP | Bcl-2/Bax | Caspase | TGF-β/Smad | TNF-α | COX | PGE | PI3K | Akt | JNK | p38MAPK
storage
Store at -20°C
References
1) Mohan?et al.?(2004),?Withaferin A is a potent inhibitor of angiogenesis; Angiogenesis, 7 115 2) Kaileh?et al.?(2007),?Withaferin A strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with inhibition of its kinase activity; J. Biol. Chem.,?282?4253 3) Bargagna-Mohan?et al.?(2007),?The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin; Chem. Biol.,?14?623 4) Thaiparambil?et al.?(2011),?Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation; Int. J. Cancer,?129?2744 5) Livne-Bar?et al.?(2016),?Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis;?Cell Death Dis.,?7?e2386
WITHAFERIN A Preparation Products And Raw materials
Raw materials
Preparation Products
WITHAFERIN A Suppliers
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- 888-539-0666
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- United States
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- Country
- United States
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View Lastest Price from WITHAFERIN A manufacturers
- Product
- Withaferin A 5119-48-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000 kg
- Release date
- 2024-04-17
- Product
- Withaferin A 5119-48-2 5119-48-2
- Price
- US $450.00/mg
- Min. Order
- 10mg
- Purity
- ≥98%
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-17
- Product
- Withaferin A 5119-48-2 5119-48-2
- Price
- US $450.00/mg
- Min. Order
- 10mg
- Purity
- ≥98%
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-17